Biotech
Biotechnology explained: gene editing, cell and gene therapy, synthetic biology, diagnostics and the companies and papers shaping the field.
Polygenic Risk Scores: What They Can Tell You, and Why They Fall Short for Individuals
Polygenic risk scores rank people by inherited risk, not by fate. A myth-versus-fact guide to what the evidence supports, with ancestry gaps…
Personalized Gene Editing After Baby KJ: From One Patient to a Possible Pathway
A timeline of personalized gene editing: baby KJ's custom base editor, the FDA's plausible mechanism draft guidance, and the prime editing platform…
Off-Target Effects in Gene Editing: How Scientists Find and Measure Them
Off-target effects are unintended gene edits. Here is how prediction, test-tube assays, cell-based methods and deep sequencing find them, and why no…
How CAR-T Therapy Works, and Why It Is Moving Into Autoimmune Disease and Solid Tumors
CAR-T therapy turns a patient's T cells into targeted hunters. A plain explainer, plus what 2026 added in lupus, stiff person syndrome…
US Drug Manufacturing in 2026: Tariffs, Plant Pledges and When Anything Actually Ships
Tariff policy has set off a wave of US plant pledges, but most open between 2027 and 2034. A plain account of…
Long-Read Sequencing: What It Finds in a Genome That Short Reads Miss
Short reads cover most of a genome but stumble on repeats and large rearrangements. Here is what long-read sequencing adds, with yields…
CRISPR-Cas9, Base Editing and Prime Editing: What Each Tool Actually Changes
Cas9 cuts, base editors swap a letter, prime editors rewrite short stretches. A plain comparison of what each tool does to DNA…
In Vivo CAR-T Explained: Making CAR T Cells Inside the Body, and What the 2026 Data Really Show
One infusion, no factory: how in vivo CAR-T turns a patient's own T cells into cancer fighters, and what small 2026 trials…
DNA Synthesis and Cell-Free Expression: How a Gene Becomes a Protein Without a Cell
From phosphoramidite chemistry to Golden Gate and Gibson assembly to cell-free protein synthesis, an evergreen guide to how a digital design becomes…
Generative Protein Design: What RFdiffusion Has Actually Built
From RFdiffusion in 2023 to de novo antibodies in 2025, here is what generative protein design has produced in the lab, with…